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<title><string language="fre"><![CDATA[Dr Claudine Blin - The innate immune function and diversity of osteoclasts]]></string></title>
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<string language="fre"><![CDATA[Osteoclasts
are the cells responsible for bone resorption in steady state and bone
destruction in chronic inflammatory diseases and osteoporosis.  Up to recently, they have been considered only
as a single population of bone-resorbing cells whose differentiation and
activity are increasing in pathologies associated with bone destruction.
However, recent data demonstrated that besides bone resorption, osteoclasts are
innate immune cells. In particular, they present antigens and activate T cell
responses towards tolerance in steady state. Moreover, they are also able to
stimulate inflammatory T cells in the context of chronic inflammation. Using
RNAseq on purified mature osteoclasts, we showed that these divergent immune
effects are related to functionally and transcriptionally distinct subsets of
osteoclasts. Therefore, bone destruction not only relies on an increased number
of osteoclasts but also on the emergence of different osteoclast subsets having
opposite immune outcomes. Taking advantage of the immune characteristics of these
different subsets and in particular their different capacity to respond to
danger signals arising from gut dysbiosis, we could specifically block the
differentiation of inflammatory osteoclasts and reduced bone destruction in
ovariectomized mice. These new data on the diversity and innate immune]]></string></description>
<keyword><string language="fre"><![CDATA[ostéoclaste]]></string></keyword>
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<date><dateTime>2021-03-23</dateTime></date>
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<string language="fre"><![CDATA[Droits réservés à l'éditeur et aux auteurs. 
@ LE STUDIUM 2021]]></string>
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<string language="fre"><![CDATA[Innate immunity in a biomineralized context: trade-offs or synergies?]]></string>
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<string language="fre"><![CDATA[Universités Numériques Thématiques 2009 http://www.universites-numeriques.fr]]></string>
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