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<title><string language="fre"><![CDATA[1.10. Overlapping sliding window]]></string></title>
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<string language="fre"><![CDATA[We have made some drawings along a genomic sequence. And we have seen that although the algorithm is quite simple, even if some points of the algorithmare bit trickier than the others, we were able to produce an interesting result that is a prediction of the origin of replication of bacterial genomes. We have seen also that it may work for a large part of bacterial genomes but for some of them it doesn't work and this is the real life of bio informaticians. We have to deal with that. But, our algorithm was very visual. Now, we want to have a more quantitative approach to make apparent the bias in G, C or A, T and so on. Not only on the visual basis buton a more quantitative basis. Let's see how we can do that. We will change the algorithm a little bit. We are already familiar withthe notion of window. So, we know how to compute nucleotidefrequencies in a sliding window. Frequencies or number ofoccurrences, it's the same thing. So, what we will do is this newversion of the algorithm is we have a window onthe genomic sequence. On this window, we are able to compute the number of G and C. This should be very easy for you right now.]]></string></description>
<keyword><string language="fre"><![CDATA[DNA]]></string></keyword><keyword><string language="fre"><![CDATA[Genome]]></string></keyword><keyword><string language="fre"><![CDATA[algorithm]]></string></keyword><keyword><string language="fre"><![CDATA[cell]]></string></keyword><keyword><string language="fre"><![CDATA[bioinformatics]]></string></keyword>
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FN:Francois RECHENMANN
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NOTE: Ingénieur et Docteur-Ingénieur en informatique, François Rechenmann est chercheur au centre Inria Grenoble – Rhône-Alpes. Il y exerce ses activités à l’interface de l’informatique et des sciences du vivant en contribuant plus particulièrement au développement de méthodes et de logiciels pour l’analyse des séquences génomiques des microorganismes. Cofondateur de la société Genostar, qui propose des solutions bioinformatiques aux industries pharmaceutiques, agroalimentaires et biotechnologiques, il en est le conseiller scientifique. Très impliqué dans les actions de médiation scientifique, François Rechenmann est le responsable scientifique du site Interstices dont l’objectif est d’expliquer l’informatique en tant que domaine de recherche. 
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<date><dateTime>2015-02-05</dateTime></date>
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<string language="fre"><![CDATA[Droits réservés à l'éditeur et aux auteurs. 
Ces ressources de cours sont, sauf mention contraire, diffusées sous Licence Creative Commons. L’utilisateur doit mentionner le nom de l’auteur, il peut exploiter l’œuvre sauf dans un contexte commercial et il ne peut apporter de modifications à l’œuvre originale.]]></string>
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